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Targeted Protein Degrader Building Blocks
PROTAC is a heterodimeric molecule, with one end of the molecule connected to a ligand that binds to a target protein, the other end connected to a ligand of an E3 ligase, and the middle connected by a suitable linker. The degradation of target proteins by PROTAC is achieved through the ubiquitin proteasome system (UPS). The general process is as follows: PROTAC molecules bind to target proteins (POI) and E3 ligases to form a ternary complex, labeling the target proteins with ubiquitination. The ubiquitinated proteins are recognized and degraded by the intracellular proteasome 26S. Currently, we offer over 300 E3 ligase ligand products and provide comprehensive PROTAC FTE services to meet customers' specific research needs.